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Rank: Advanced Member
Groups: Registered
Joined: 10/19/2010
Posts: 88
Location: Saddleworth, UK
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Hello All,
After recently attending my GP surgery for my usual monthly bloods I was alerted by the nurse to a potentially life threatening reaction whilst taking MTX injections.
Trimethoprim is an antibiotic usually prescribed for UTI's, Urine, bladder and Kidney infections. It increases mtx toxicity making it life threatening. I have copied and pasted an abstract from the pharmaceutical company:
MTX and TS is an extremely serious and life-threatening combination that should be avoided. Practical recommendations regarding MTX use can be established to prevent harm from drug interactions. Increasing awareness of physicians, pharmacist and patients is essential to assure safe and effective MTX therapy.
Also more alarming info was that the GP surgery database did not state that I was taking MTX inj, as it isn't prescribed by them but by my Rheumy and BUPA.
PLEASE PLEASE PLEASE make everyone in your family aware that you are not to have Trimethoprim if you are on MTX. AND if you have the injs delivered by BUPA please ensure that your GP surgery makes a note to alert all prescribers, similar the the allergy alert!
After that bombshell I wish you luck!
Hope you are all coping with the end of summer (as I am NOT!!!)
Lxxx
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Rank: Advanced Member
Groups: Registered
Joined: 8/1/2010
Posts: 255
Location: hampshire
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Hi Louise That is a very useful warning. We all hope our GP is alert to potential risks with drugs but whenever I get prescribed anything I always ask if it is OK with mtx -just in case. Sue 
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Rank: Advanced Member  Groups: Registered
Joined: 2/7/2013 Posts: 71 Location: Suffolk.
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I have had the same issue with the GP not recognising the MTX when they prescribe. I was also accidentally prescribed a combination that can damage your heart, and only found out when an on the ball GP spotted it.
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Rank: Advanced Member  Groups: Registered
Joined: 12/3/2009 Posts: 838 Location: Nottinghamshire
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Thanks for the warning.
I heard a story a while back on another forum that a ladies Humira was not on her GP records because the hospital did the prescriptions and not them. If you are having any drug prescribed by the hospital it is best to check that it is on your patient records at your GP's surgery.
I know mine is because when I order my folic acid and stomach protector at the chemist (Boots do it all for me), MTX and my Enbrel is listed on the order slip attached to the prescription
I thought that the one I knew about was a one off, but obviously not, so CHECK all your drugs are listed. It's better to be safe than sorry.
Paula
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